Most Played Medical Sim Games on Steam
Take a look at the top medical sim games that are currently attracting the largest player bases on the Steam platform, as of September 15th 2025. Want to explore even more medical sim titles available on Steam? Explore the complete list of the best medical sim games.
Lists & Categories
1. Two Point Hospital
Design stunning hospitals, cure peculiar illnesses and manage troublesome staff as you spread your budding healthcare organisation across Two Point County. Two Point Hospital is a game developed and published by . Released on August 29th 2018 has received 33,274 reviews of which 30,563 were positive and 2,711 were negative resulting in an impressive rating of 9 out of 10. The game has hit the top spot as the #1 most played medical sim game, thanks to its 479 peak concurrent players over the last day.
9
30,563
2,711
479
players
2. Project Hospital
Become an ace doctor, an aspiring architect and a successful manager at the same time. Design your very own hospital, tweak every detail or choose one of the prebuilt scenarios and just jump to the doctor’s duty. Project Hospital is a game developed and published by . Released on October 30th 2018 has received 8,348 reviews of which 7,392 were positive and 956 were negative resulting in a rating of 8.6 out of 10. While seeing 269 players online at once in the last 24 hours, this game is currently ranked #2 among medical sim games based on player count.
8.6
7,392
956
269
players
3. Do No Harm
Lovecraftian Doctor Simulator. Diagnose patients by analyzing unsettling symptoms and treat them using your Book of Medicine. Make moral choices — decide who to save or kill, discover whom to trust, and unlock multiple endings! Can you endure 30 days of perilous decisions? Do No Harm is a game developed and published by . Released on March 06th 2025 has received 599 reviews of which 443 were positive and 156 were negative resulting in a rating of 7.1 out of 10. The game currently holds the #3 spot among the most played medical sim games.
7.1
443
156
23
players
4. Surgeon Simulator
Surgeon Simulator is an over-the-top operation sim, stitching together pitch-black humour with life-saving surgery. Become Dr. Burke, a would-be surgeon with a less than conventional toolkit, as he performs procedures on patients including the Heavy from TF2! ...is that a hammer? Surgeon Simulator is a game developed and published by . Released on April 19th 2013 has received 16,493 reviews of which 13,566 were positive and 2,927 were negative resulting in a rating of 8.1 out of 10. The game currently holds the #4 spot among the most played medical sim games.
8.1
13,566
2,927
14
players
5. Big Pharma
What if you had it in your power to rid the world of disease, to improve the lives of millions, to ease suffering and cure the sick… and earn a tidy profit? As the head of your own Pharmaceutical Conglomerate you have this power resting in your hands. Will you use it for good? Big Pharma is a game developed and published by . Released on August 27th 2015 has received 1,883 reviews of which 1,458 were positive and 425 were negative resulting in a rating of 7.5 out of 10. The game currently holds the #5 spot among the most played medical sim games.
7.5
1,458
425
14
players
6. Weedcraft Inc
Weedcraft Inc explores the business of producing, breeding and selling weed in America, delving deep into the financial, political and cultural aspects of the country's complex relationship with this troublesome and promising plant. Weedcraft Inc is a game developed and published by . Released on April 11th 2019 has received 1,632 reviews of which 1,311 were positive and 321 were negative resulting in a rating of 7.7 out of 10. The game currently holds the #6 spot among the most played medical sim games.
7.7
1,311
321
9
players
7. Bio Inc. Redemption
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity? Bio Inc. Redemption is a game developed and published by . Released on March 08th 2018 has received 2,307 reviews of which 2,058 were positive and 249 were negative resulting in a rating of 8.5 out of 10. The game currently holds the #7 spot among the most played medical sim games.
8.5
2,058
249
7
players
8. Galacticare
Build, manage and optimise intergalactic hospitals! Recruit staff to satisfy the whims of various alien species, and cure their bizarre illnesses - for money! Save the (literal) Galaxy in story mode, or head into sandbox to design the hospital of your dreams. Galacticare is a game developed and published by . Released on May 23rd 2024 has received 570 reviews of which 503 were positive and 67 were negative resulting in a rating of 8.3 out of 10. The game currently holds the #8 spot among the most played medical sim games.
8.3
503
67
5
players
9. Heart's Medicine - Time to Heal
An intense, but also funny, medical drama that deals with a lot of life-changing decisions. Become an aspiring surgeon at Little Creek Hospital! Heart's Medicine - Time to Heal is a game developed and published by . Released on September 20th 2016 has received 868 reviews of which 816 were positive and 52 were negative resulting in a rating of 8.8 out of 10. The game currently holds the #9 spot among the most played medical sim games.
8.8
816
52
4
players
10. Night Shift Nurses
A washed-up mad doctor is hired back by a devious former test subject and asked to twist her hospital into a corrupt donation mill. Will he seize this second chance to practice his own vision of "science," or will his many failings drag him down once again in this pseudo-medical visual novel? Night Shift Nurses is a game developed and published by . Released on December 16th 2024 has received 438 reviews of which 376 were positive and 62 were negative resulting in a rating of 8.0 out of 10. The game currently holds the #10 spot among the most played medical sim games.
8.0
376
62
4
players
More Medical Sim & Related Games
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