Most Played Outbreak Sim Games on Steam
Take a look at the top outbreak sim games that are currently attracting the largest player bases on the Steam platform, as of July 30th 2025. Want to explore even more outbreak sim titles available on Steam? Explore the complete list of the best outbreak sim games.
Lists & Categories
1. Plague Inc: Evolved
Plague Inc: Evolved is a unique mix of high strategy and terrifyingly realistic simulation. Your pathogen has just infected 'Patient Zero' - now you must bring about the end of human history by evolving a deadly, global Plague whilst adapting against everything humanity can do to defend itself. Plague Inc: Evolved is a game developed and published by . Released on February 18th 2016 has received 55,664 reviews of which 52,571 were positive and 3,093 were negative resulting in an impressive rating of 9.3 out of 10. The game has hit the top spot as the #1 most played outbreak sim game, thanks to its 835 peak concurrent players over the last day.
9.3
52,571
3,093
835
players
2. After Inc: Revival
Can you rebuild civilisation after a zombie apocalypse? From the creator of Plague Inc. comes a unique blend of strategic simulation, survival city builder and ‘mini 4X’. Build settlements, harvest resources and shape society as you lead Humanity out of the darkness. After Inc: Revival is a game developed and published by . Released on June 17th 2025 has received 630 reviews of which 494 were positive and 136 were negative resulting in a rating of 7.4 out of 10. The game currently holds the #2 spot among the most played outbreak sim games.
7.4
494
136
100
players
3. Bio Inc. Redemption
Bio Inc.: Redemption is a realistic simulation and strategy game in which you make life or death decisions. Create a deadly illness to infect and torment your victim or play as the head of a medical team and hopefully find a cure to save your human patient. Will you be the plague or preserve humanity? Bio Inc. Redemption is a game developed and published by . Released on March 08th 2018 has received 2,307 reviews of which 2,058 were positive and 249 were negative resulting in a rating of 8.5 out of 10. The game currently holds the #3 spot among the most played outbreak sim games.
8.5
2,058
249
25
players
4. 60 Seconds!
60 Seconds! is a dark comedy atomic adventure of scavenge and survival. Collect supplies and rescue your family before the nuke hits. Stay alive in your fallout shelter. Make difficult decisions, ration food and hunt mutant cockroaches. And maybe survive. Or not. 60 Seconds! is a game developed and published by . Released on May 25th 2015 has received 11,517 reviews of which 9,749 were positive and 1,768 were negative resulting in a rating of 8.3 out of 10. The game currently holds the #4 spot among the most played outbreak sim games.
8.3
9,749
1,768
17
players
5. Infectonator 3: Apocalypse
A campy, crazy pixelart zombie apocalypse arcade sim where you're the bad guy. Drop your virus and spread it across the globe while you unlock a whole horde of bizarre undead to do your bidding. Infectonator 3: Apocalypse is a game developed and published by . Released on May 10th 2018 has received 1,136 reviews of which 943 were positive and 193 were negative resulting in a rating of 7.9 out of 10. The game currently holds the #5 spot among the most played outbreak sim games.
7.9
943
193
8
players
6. Galacticare
Build, manage and optimise intergalactic hospitals! Recruit staff to satisfy the whims of various alien species, and cure their bizarre illnesses - for money! Save the (literal) Galaxy in story mode, or head into sandbox to design the hospital of your dreams. Galacticare is a game developed and published by . Released on May 23rd 2024 has received 570 reviews of which 503 were positive and 67 were negative resulting in a rating of 8.3 out of 10. The game currently holds the #6 spot among the most played outbreak sim games.
8.3
503
67
3
players
7. The Fabulous Fear Machine
The Fabulous Fear Machine is a narrative-driven strategy game with a pulp horror style. As the Machine's new Master, you must sow fear and expand your influence by creating Legends, harvesting resources, manipulating events, and spying on your enemies. The Fabulous Fear Machine is a game developed and published by . Released on October 04th 2023 has received 519 reviews of which 469 were positive and 50 were negative resulting in a rating of 8.4 out of 10. The game currently holds the #7 spot among the most played outbreak sim games.
8.4
469
50
2
players
More Outbreak Sim & Related Games
Love Outbreak Sim games? Dive into even more! Our extensive collection is ready to be explored with these easy links. Filter by price, uncover new titles and grab incredible deals to pinpoint your ideal game.