Games like Protolife on Steam
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From Glory To Goo
From Glory To Goo is a Sci-Fi survival RTS set on an alien world. Serve as humanity's bulwark by establishing a colony and supporting your colonists still in orbit. But beware, for The Goo, a relentless and shape-shifting force approaches from all sides, even above and below.
Space Run
Space Run is a «real-time spaceship construction strategy game». Space Run takes the well-known Tower Defense-style gameplay and twists it, challenging you to manage and protect a spaceship and its cargo against the hazards of deep space!
Rise to Ruins
A brutal godlike village sim that melds the god game, management, and tower defense genres! Fight off hoards of monsters at night, and expand your village in the day time. Inspired by games like Black and White, Rimworld, and Dwarf Fortress but not quite like any of them.
METAL SLUG ATTACK RELOADED
Hard-core action with easy controls! The METAL SLUG we all love is back as a tower defense game!
Anomaly Defenders
Anomaly Defenders is the closing installment of the Anomaly series. The original incarnation of the Tower Offense sub-genre had players controlling humans fighting alien invaders. Now, the tables have turned. The human counterattack is underway and the alien homeworld is under threat.
Unstoppable Gorg
Defend the solar system from fearsome aliens by sending satellites into orbit in revolutionary tower defense action!
Supreme Commander: Forged Alliance
The last days of man are at hand.. Two years after the Infinite War the once great warring nations now lie in ruins, and humanity’s hope for a brighter future is nothing but a bitter memory. A new, seemingly unstoppable enemy, supported by the zealots of The Order, now seeks to eradicate mankind: UEF, Aeon Loyalist, and Cybran alike.
There Came an Echo
There Came an Echo is a real-time strategy game in which the player assumes command of a small squadron, using an advanced voice recognition system to issue orders. It features a character-driven sci-fi narrative that stars Wil Wheaton, Ashly Burch, Laura Bailey, Yuri Lowenthal, and more!
Aegis Defenders
Take on wild beasts, ruthless soldiers, and ancient gods in this 2D Action-Platformer inspired by Tower-Defense combat.
Pixel Gladiator
Distant future… Brutal gladiatorial battles is a top-rated show, extremely popular all over the Universe. You’ve been sent to the abandoned planet as one of the participants of the show. Your goal is to survive as long as possible, fighting back deadly creatures in the focus of billions of viewers.
Iron Marines
Real-time strategy battles in amazing sci-fi worlds! Command brave soldiers, mighty mechas and powerful aliens to face the greatest challenges in hostile alien worlds. The galaxy needs you!
Until We Die
Until We Die is a side-scrolling strategy game about defending your base where you have to run around as Ivan, assign tasks to people, and fight mutants in the post-apocalyptic subway!
Supreme Commander 2
Includes 47 Steam achievements, leaderboards, and stats!
Original War
An American geological expedition, under a UN mandate, assesses the natural resources in a distant part of Siberia, deep in the trackless steppes of Eastern Russia. But instead of oil, they discover a deposit of a hitherto unknown mineral.
Warhammer 40,000: Dawn of War - Anniversary Edition
All of Warhammer 40,000: Dawn of War in one glorious package. Play the genre-defining classic real time strategy game in all its blood-soaked glory, including four complete campaigns and nine full-fledged factions.
Grim Nights
Your village must survive for 13 days! Gather resources, expand, explore the underground for riches, and train soldiers to defend against hordes of the undead.
Anomaly Warzone Earth Mobile Campaign
Anomaly Warzone Earth Mobile Campaign continues Steam's Anomaly Warzone Earth in an extra 15-level campaign. Originally released on mobile devices, the campaign is brought to Steam for PC, Mac and Linux exclusively in Anomaly Bundle. AWE Mobile Campaign turns tower defense on its head.
Mushroom Wars 2
In Mushroom Wars 2, enemy tribes of feisty mushroom creatures face off in short but fierce RTS battles. Step into the shoes of a fearless Mushroom Commander, choose a hero to lead your army, and take control of the battlefield in a variety of multiplayer modes or challenging story campaign.
OF MICE AND SAND -REVISED-
On a desert planet in the farthest reaches of space, mice await your command! Direct their mobile fortress, and seek the legendary city of gold!
Super Sanctum TD
Super Sanctum TD is a retro-styled Tower Defense game that focuses on strategy, customization and replayability. Build advanced mazes and construct powerful towers to prevent alien hordes from reaching the Core!
War, the Game
'War, the Game' is a RTS for pc in realistic present day setting.The controls are intuitive, the game rules are simple and transparent.The game focuses on strategy and the use of ones brain to complete the scenarios.The map is a spherical version of earth. That's new.
Age of Darkness: Final Stand
Age of Darkness: Final Stand is a dark fantasy survival RTS where you must illuminate, build and defend humanity’s last bastion against hordes of Nightmares. Set in the remnants of a kingdom consumed by a deadly fog, you decide. Will you hide in the light? Or take back your world.
Act of Aggression - Reboot Edition
Act of Aggression – Reboot Edition brings the techno-thriller RTS game Act of Aggression to a higher level. The Reboot Edition offers a full gameplay overhaul in skirmish mode against the AI and in your multiplayer battles.
Tempest Rising
Command distinct factions in a desperate struggle for power and resources in Tempest Rising - a classic RTS set on Earth after a nuclear war.
Defend Your Life: TD
Defend Your Life! Is tower defense set in human body where players are fighting against villain hordes of viruses and bacteria. Levels and units correspond to reality of human anatomy.
Creeper World 2: Anniversary Edition
Deceptively simple... amazingly deep. Creeper World 2 thrusts you into the 14th millennium fighting and enemy that flows and oozes through the terrain. Employ advanced weapons,gravity manipulating repulsors, wormhole like rifts, and your own wit against this never yielding enemy.
Particula
Destroy negativity, clear your mind! Particula brings you a new perspective in gaming, helping you to concentrate and relax. A three players co-op tower defense experience with a relaxing soundtrack, smooth visuals and gameplay.
GemCraft - Chasing Shadows
An epic, challenging tower defense game with an emphasis on strategy and replayability. Summon gems of immense magical potency and harness their unique abilities against a seemingly endless horde of monsters. The archdemon seeks to swallow the world, and you must journey to stand against her.
The White Laboratory
The White Laboratory is a sandbox style physics-based tower defense and RTS game in which you modularly build and command robotic structures. Use them to defend against or conquer other disobedient mechanical blocks on a facility floating in the atmosphere of a remote gas planet.
Death Crown
Death Crown is a minimalist real time strategy game in a 1bit style, where you will be play Death herself, commanding her legions of death, and punishing humanity's Kingdom for its overconfidence.
Planetary Annihilation: TITANS
Wage war across entire solar systems with massive armies at your command. Annihilate enemy forces with world-shattering TITAN-class units, and demolish planets with massive super weapons!
No Creeps Were Harmed TD
Employ lethal turrets, traps, and gadgets to defend against an onslaught of evolving creeps! Step into a twisted, hyper 3D, mind bending realm. Upgrade and adapt your defenses. Become a master maze crafter. Collect bizarre artifacts. Rush creeps for lucrative rewards, and succumb to greed!